What You Should Know About Liver Health

The liver performs more than 500 vital functions, including detoxification, metabolism, and immune regulation—earning it the nickname “the body’s chemical factory.” Yet because it rarely causes noticeable pain until significant damage has occurred, it is often referred to as the “silent organ.”

One of the most objective indicators of liver health is serum albumin. Albumin is a protein synthesized exclusively by liver cells, and when liver function declines, changes in albumin levels are often among the earliest signs. Recently, decreasing albumin levels have drawn attention not merely as a marker of poor nutrition, but as a signal associated with systemic inflammation and an increased risk of chronic disease.

Low Albumin Levels Increase Chronic Inflammation and Cardiovascular Risk

Albumin not only transports nutrients throughout the body but also plays a crucial antioxidant role by neutralizing reactive oxygen species. In addition, it binds to and helps detoxify harmful substances such as bilirubin. A low albumin level indicates that both the body’s detoxification and defense systems may be compromised.

According to findings published in the international journal Basic & Clinical Pharmacology, lower serum albumin levels are significantly associated with elevated C-reactive protein (CRP), a key marker of inflammation. Reports also suggest that individuals whose albumin levels remain near the lower limit of normal (around 3.5 g/dL) may face a relatively higher risk of metabolic syndrome and cardiovascular disease. Some analyses indicate that for every 0.1 g/dL decrease in albumin, the body’s overall homeostasis becomes more vulnerable, increasing the likelihood of chronic inflammatory states.

Influencing Immunity and Cognitive Function: Managing Albumin and Choosing the Right Product

Albumin helps create an optimal plasma environment for immune cell activity and contributes to the structural stability of immunoglobulins. In studies involving older adults, lower albumin levels were associated with reduced antibody formation following vaccination. This suggests that hypoalbuminemia may weaken the body’s defense against external viral threats.

Albumin also plays a role in maintaining cerebral blood flow and regulating substance transport across the blood–brain barrier. When levels decline, it may contribute to chronic fatigue, decreased concentration, and so-called “brain fog” symptoms.

When considering albumin supplementation, careful product selection is essential. First, verify that the raw materials meet national quality control standards. Differences in formulation can also affect absorption. Tablets and powders require digestion and breakdown in the body, whereas liquid formulations are absorbed more rapidly and may place less burden on the gastrointestinal tract—making them relatively suitable for older adults or individuals with reduced vitality.

Experts advise that rather than attempting urgent correction after albumin levels have significantly declined, maintaining levels consistently through highly concentrated, well-absorbed formulations as part of routine health management is a more prudent approach.

Source: 동아일보 (https://www.donga.com/)